Take the motorway towards ITALY- MILAN following the signs for MENDRISIO-VARESE. After the Mendrisio exit, leave the motorway at Genestrerio exit and follow the direction to GENESTRERIO- BIZZARONE.
At Bizzarrone, cross the border from Switzerland into Italy. Continue on the same road for approximately 7Km.You will reach a big roundabout crossed by the Varese-Como road SS342 (direction to Varese if you take the right, direction to Como on the left). Go straight on (on your right there is a shopping-center called Brico) and approximately 50 meters after the roundabout take a narrow road on the right (Via Marconi). After about 500 meters turn left into Via Grandi .
After 100 meters you will find Sisme on the left.